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August 11, 2011
Novel Targeted Agents In Soft Tissue Sarcoma.

We are again speaking with Dr. John Eckardt on novel targeted agents in soft tissue sarcoma. 

Welcome to the Oncology Network for Excellence. We are again speaking with Dr. John Eckardt on novel targeted agents in soft tissue sarcoma. Dr. Eckardt, in recent years, several previously unmet needs have been fulfilled as new targeted agents have emerged. Still today, one area of unmet need is sarcoma. Can you tell us what progress has been made in this area recently?

June 1, 2011
Chromosomes 2 and 5
June 1, 2011
EML4/ Alk
June 1, 2011
PDGF Signal Transduction
June 1, 2011
PDGFR Downstream Signalling
June 1, 2011
Signet Adenocarcinoma Cells
May 31, 2011
Animation on EML4/ALK fusion

An inversion in chromosome 2 that juxtaposes the 5' end of the EML4 gene with the 3' end of the ALK gene, resulting in the novel fusion oncogene EML4-ALK.

inversion in chromosome 2 that juxtaposes the 5' end of the echinoderm microtubule-associated protein-like 4 (EML4) gene with the 3' end of the anaplastic lymphoma kinase (ALK) gene, resulting in the novel fusion oncogene EML4-ALK.